7-Methoxyquinoline → 7-Methoxy-1,2,3,4-tetrahydroquinoline

HRID 1520178노트

반응식

HRID 1520178 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>CO.O=[Pt]=O>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][NH:10]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 1

HCID 786667-Methoxyquinoline

생성물 1

HCID 162443887-Methoxy-1,2,3,4-tetrahydroquinoline수율 73.2%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

To a solution of 7-methoxyquinoline (2.0 g, 12.56 mmol) in methanol (60 ml) was added PtO2 (180 mg, 0.79 mmol). H2 (g) was introduced into above solution and the reaction was stirred overnight at room temperature and then the solids were filtered off. The organics were concentrated in vacuo to give a residue, which was purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether to afford 7-methoxy-1,2,3,4-tetrahydroquinoline as a light yellow oil (1.5 g, 73%).

후처리

  1. additionH2 (g) was introduced into above solution
  2. filtrationthe solids were filtered off
  3. concentrationThe organics were concentrated in vacuo
  4. customto give a residue, which
  5. customwas purified by silica gel column chromatography with 3% ethyl acetate in petroleum ether

출처 및 근거

ORD 기록
ord-762f89ecda7745aba699fc390fd16151
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073902B2

반응 노트

불러오는 중…