Tris(furan-2-yl)phosphane → 2,2-Difluoro-N-[(1S,2R)-1-fluoromethyl-2-hydroxy-2-(4-{6-[(methanesulfonyl-methoxy-amino)-methyl]-pyridin-3-yl}-phenyl)-ethyl]-acetamide

반응식

Br[C:2]1[CH:3]=[CH:4][C:5]([CH2:8][N:9]([O:14][CH3:15])[S:10]([CH3:13])(=[O:12])=[O:11])=[N:6][CH:7]=1.[F:16][CH:17]([F:36])[C:18]([NH:20][C@H:21]([CH2:34][F:35])[C@H:22]([OH:33])[C:23]1[CH:28]=[CH:27][C:26]([Sn](C)(C)C)=[CH:25][CH:24]=1)=[O:19].O1C=CC=C1P(C1OC=CC=1)C1OC=CC=1>CN1CCCC1=O.O.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[F:16][CH:17]([F:36])[C:18]([NH:20][C@H:21]([CH2:34][F:35])[C@H:22]([OH:33])[C:23]1[CH:24]=[CH:25][C:26]([C:2]2[CH:7]=[N:6][C:5]([CH2:8][N:9]([S:10]([CH3:13])(=[O:12])=[O:11])[O:14][CH3:15])=[CH:4][CH:3]=2)=[CH:27][CH:28]=1)=[O:19]