3-Chlorobenzaldehyde → Benzaldehyde, m-chloro-, oxime, (Z)-

HRID 1521072노트

반응식

HRID 1521072 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.Cl.[NH2:11][OH:12].C([O-])(=O)C.[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)/[CH:5]=[N:11]\[OH:12]

참가 물질

5

반응물 3

HCID 114773-ChlorobenzaldehydeHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 5372364Benzaldehyde, m-chloro-, oxime, (Z)-수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a suspension of 3-chlorobenzaldehyde (50 g, 355 mmol) and hydroxylamine hydrochloride (38 g, 543 mmol) in ethanol (200 mL) containing sodium acetate (46 g, 558 mmol) was heated under reflux for 3 h. After 30 min stirring at room temperature a white solid precipitated and the resulting mixture was then diluted with water and acidified with HCl (4 N). The white precipitate was then filtered off, washed with water and dried under high vacuum to afford the title compound (54 g, 98%) which was obtained as a white solid. Mp: 64-66° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 h
  3. customprecipitated
  4. additionthe resulting mixture was then diluted with water
  5. filtrationThe white precipitate was then filtered off
  6. washwashed with water
  7. customdried under high vacuum

출처 및 근거

ORD 기록
ord-c456e2d5ec564165950810750bdbf0bd
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09073908B2

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