N-bromobutanimide → 6-bromo-5-cyclopropyl-3,4-dihydroquinolin-2(1H)-one
반응식
[CH:1]1([C:4]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:5]=2[CH2:6][CH2:7][C:8](=[O:14])[NH:9]3)[CH2:3][CH2:2]1.[Br:15]N1C(=O)CCC1=O>CN(C)C=O>[Br:15][C:13]1[C:4]([CH:1]2[CH2:3][CH2:2]2)=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:14])[CH2:7][CH2:6]2참가 물질
4
실험 절차
To a stirred solution of 5-cyclopropyl-3,4-dihydroquinolin-2(1H)-one (147-5; 0.5 g, 0.00267 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinimide (0.47 g, 0.0026 mol) portion wise at 0° C. Reaction mixture was allowed to stir at room temperature for 4 h. The reaction mixture was concentrated and diluted with ice cold water (100 mL) with constant stirring, the solid residue obtained was filtered and dried to obtain the title compound. MS (M+1): 266.1.
후처리
- customReaction mixture
- concentrationThe reaction mixture was concentrated
- additiondiluted with ice cold water (100 mL) with constant stirring
- customthe solid residue obtained
- filtrationwas filtered
- customdried
출처 및 근거
- ORD 기록
- ord-9db4c85d43d6475e8515f7be83bbcdf5
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09073929B2
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