Water → 2-(2-Fluoro-3-methoxyphenyl)acetic acid

HRID 1522884노트

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HRID 1522884 반응식
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]#N.[OH-:13].[Na+].[OH2:15]>CO>[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:10][C:11]([OH:15])=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 230744722-(2-Fluoro-3-methoxyphenyl)acetonitrile

생성물 1

HCID 230744162-(2-Fluoro-3-methoxyphenyl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

To a mixture of 2-(2-fluoro-3-methoxyphenyl)acetonitrile (6.7 g, 40.6 mmol) in water (40 mL) and methanol (40 mL), sodium hydroxide (3.2 g, 81.1 mmol) was added. The resulting mixture was stirred at 60° C. for 5 h. After cooling to room temperature, methanol was evaporated under reduced pressure. The residue was acidified with 10% HCl until pH 5. The resulting precipitate was collected by filtration and dried to afford the title compound (6.3 g).

후처리

  1. additionwas added
  2. temperatureAfter cooling to room temperature
  3. custommethanol was evaporated under reduced pressure
  4. filtrationThe resulting precipitate was collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-82204c55c96e44a0a106ecb371bd5bbf
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09078871B2

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