Hydrogen Bromide → (R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

반응식

C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:15]>>[BrH:15].[OH:2][C:3]1[CH:4]=[C:5]([CH2:11][C@H:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[OH:9]

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 117694083,4-Dma, (R)-

생성물 1

HCID 67643451(R)-3-(3,4-Dihydroxyphenyl)-2-propylamine hydrobromide

실험 절차

A solution of (R)-3-(3,4-dimethoxyphenyl)-2-propylamine hydrochloride1 (500 mg, 2.15 mMol) in hydrogen bromide (48%, 5 ml) was stirred at 100° C. under an argon atmosphere for 20 hours. After cooling, the solvent was evaporated and the residue was dried giving the title compound.

후처리

temperatureAfter cooling
customthe solvent was evaporated
customthe residue was dried

출처 및 근거

ORD 기록: ord-a3c93df638364213adea34d2adfb06d5
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05726165

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