Hydrazine hydrate (1:1) → HCID 86724908, 화합물

HRID 1523717노트

반응식

HRID 1523717 반응식
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=O)=[N:5]1)([CH3:3])[CH3:2].O.[NH2:18][NH2:19]>C(O)C>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([NH:18][NH2:19])=[O:15])=[N:5]1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 10680335HCID 10680335, 화합물

생성물 1

HCID 86724908HCID 86724908, 화합물수율 6,715.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of methyl 1-isopropyl-1H-indazol-3-yl carboxylate (40.0 grams, 183.5 mmol, obtained in above step) in ethanol at room temperature hydrazine hydrate (130 mL, 2.56 mmol) was added. The reaction mixture was refluxed for 2 hours. The volatiles were removed under reduced pressure and the crude mass was diluted with dichloromethane, washed with water, brine, dried over anhydrous sodium sulphate and the solvent was removed under reduced pressure to obtain the title compound (37.52 grams).

후처리

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. customThe volatiles were removed under reduced pressure
  3. additionthe crude mass was diluted with dichloromethane
  4. washwashed with water, brine
  5. dry with materialdried over anhydrous sodium sulphate
  6. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-4dfb8bb93adf48499c73af397eb0ecc4
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079894B2

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