Diisopropylethylamine → tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

HRID 1523762노트

반응식

HRID 1523762 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](Cl)(=[O:10])=[O:9].[NH:12]1[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:14][CH2:13]1.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([N:12]1[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[CH2:16][CH2:17]1)(=[O:10])=[O:9]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 5204032-Bromobenzenesulfonyl chlorideHCID 7238334-(N-Boc-amino)piperidine

생성물 1

HCID 40175560tert-Butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-bromobenzene-1-sulfonyl chloride (50 mg, 0.20 mmol), tert-butyl piperidin-4-ylcarbamate (49 mg, 0.25 mmol), and diisopropylethyl amine (0.101 mL, 0.59 mmol) in CH2Cl2 was stirred for 90 min at rt. The reaction mixture was then concentrated to dryness to give the title compound in quantitative yield. The product was used without further purification.

후처리

  1. concentrationThe reaction mixture was then concentrated to dryness

출처 및 근거

ORD 기록
ord-edf99ffd6d2d48e69cf4ddaa2ccdc846
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079866B2

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