Diisopropylethylamine → trans-3-(3-Cyano-phenylcarbamoyl)-4-(3-methoxycarbonyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([C:13](=[O:23])[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=2)[C@H:10]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26](Br)[CH:25]=2)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[OH:32].C1[CH2:37][O:36][CH2:35]C1.C(N(CC)C(C)C)(C)C>CCOC(C)=O.CC1C(P(C2C([CH2-])=CC=CC=2)C2C(C)=CC=CC=2)=CC=CC=1.CC1C(P(C2C([CH2-])=CC=CC=2)C2C(C)=CC=CC=2)=CC=CC=1.CC(O)=O.CC(O)=O.[Pd].[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][C@@H:10]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:35]([O:36][CH3:37])=[O:32])[CH:25]=2)[C@H:11]([C:13](=[O:23])[NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]#[N:22])[CH:16]=2)[CH2:12]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]