Water → Methyl 3-methoxy-5-(trifluoromethyl)benzoate

HRID 1524589노트

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HRID 1524589 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5](O)=[O:6].CI.[C:17](=O)([O-])[O-].[K+].[K+].O.CN([CH:27]=[O:28])C>>[CH3:17][O:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[C:5]([O:28][CH3:27])=[O:6]

참가 물질

6

반응물 5

HCID 962WaterHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 27831463-hydroxy-5-(trifluoromethyl)benzoic Acid

생성물 1

HCID 46311161Methyl 3-methoxy-5-(trifluoromethyl)benzoate

실험 절차

3-Hydroxy-5-trifluoromethylbenzoic acid (2 g) was initially charged at RT in DMF (15 ml) while stirring, and admixed dropwise with methyl iodide (3.0 ml). After adding potassium carbonate (5.6 g), the mixture was stirred for 5 h and left to stand overnight. It was then admixed with water and extracted three times with MtB ether. The combined MTB ether phases were dried over sodium sulfate, filtered and concentrated. 2.29 g of the title compound were obtained.

후처리

  1. stirringthe mixture was stirred for 5 h
  2. waitleft
  3. extractionextracted three times with MtB ether
  4. dry with materialThe combined MTB ether phases were dried over sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4987a1ece2184cf085b346164d55b680
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079906B2

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