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Hydrochloric Acid → (R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride

HRID 1525
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HRID 1525 반응식
[CH2:1]([O:3][C:4]([C:6]1([C:26]([O:28][CH2:29][CH3:30])=[O:27])[O:10][C:9]2[CH:11]=[CH:12][C:13]([CH2:15][C@H:16]([NH:18]C(OC(C)(C)C)=O)[CH3:17])=[CH:14][C:8]=2[O:7]1)=[O:5])[CH3:2].C(OCC)C.[ClH:36]>C(OCC)(=O)C>[ClH:36].[NH2:18][C@H:16]([CH3:17])[CH2:15][C:13]1[CH:12]=[CH:11][C:9]2[O:10][C:6]([C:26]([O:28][CH2:29][CH3:30])=[O:27])([C:4]([O:3][CH2:1][CH3:2])=[O:5])[O:7][C:8]=2[CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 54476420(R)-5-[N-(t-Butyloxycarbonyl)-2-aminopropyl]-1,3-benzodioxole-2,2-dicarboxylic acid, diethyl ester

생성물 1

HCID 67642885(R)-5-(2-aminopropyl)-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of (R)-5-[N-(t-butyloxycarbonyl)-2-aminopropyl]-1,3-benzodioxole-2,2-dicarboxylic acid diethyl ester (3.0 g, 7 mMol) in ethyl acetate (40 ml) and hydrogen chloride solution in diethyl ether (1M, 56 ml, 56 mMol) was stirred at ambient temperature under an argon atmosphere for 48 hours. The solvent was evaporated and the residue was dried giving the title compound as a glass.

후처리

  1. customThe solvent was evaporated
  2. customthe residue was dried

출처 및 근거

ORD 기록
ord-bd1ea3526e084bb093238986ab53097a
출처 데이터셋
uspto-grants-1998_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05726165

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