Sodium Hydroxide → HCID 89501036, 화합물

HRID 1525359노트

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HRID 1525359 반응식
[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([N:14]2[CH:18]=[N:17][N:16]=[N:15]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([O:12]C)=[O:11])[CH:7]=1.[OH-].[Na+]>CO.C1COCC1>[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([N:14]2[CH:18]=[N:17][N:16]=[N:15]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])[CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 89501016HCID 89501016, 화합물

생성물 1

HCID 89501036HCID 89501036, 화합물수율 42.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To Intermediate 5C (5 g, 17.7 mmol) in MeOH (50 mL) and THF (25 mL) was added 10% NaOH solution (25 mL). After 2 h, the reaction was concentrated and the residue was diluted with H2O. The pH was adjusted to 2 to 3 with 1.5 N HCl and the resultant solid was filtered and washed with petroleum ether to afford 2 g of Intermediate 5. MS (ESI) m/z: 269.0 (M+H)+.

후처리

  1. concentrationthe reaction was concentrated
  2. additionthe residue was diluted with H2O
  3. filtrationthe resultant solid was filtered
  4. washwashed with petroleum ether

출처 및 근거

ORD 기록
ord-f113eadd17b046029e4aaa97ee2043d0
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09079929B2

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