Benzyl Alcohol → 4-(Benzyloxy)-2-bromonicotinonitrile

HRID 1526139노트

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HRID 1526139 반응식
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Br:11][C:12]1[N:19]=[CH:18][CH:17]=[C:16](Br)[C:13]=1[C:14]#[N:15]>CN(C=O)C>[CH2:3]([O:10][C:16]1[C:13]([C:14]#[N:15])=[C:12]([Br:11])[N:19]=[CH:18][CH:17]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 574595912,4-Dibromopyridine-3-carbonitrile

생성물 1

HCID 230886954-(Benzyloxy)-2-bromonicotinonitrile수율 83.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
0 °C

실험 절차

To a suspension of NaH (1.756 g, 45.818 mmol, mineral oil 60%) in DMF (200 ml) cooled at 0° C., was added benzyl alcohol (4.542 g, 42 mmol). The resulting mixture was stirred for 5 min. Then, intermediate compound D1 (10 g, 38.18 mmol) was added. The resulting reaction mixture was gradually warmed to r.t. and stirred for 1 h, then quenched with NH4Cl (aqueous sat. solution) and diluted with H2O. The resulting mixture was extracted with Et2O. The organic layer was separated, dried (Na2SO4) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel; DCM/7M solution of NH3 in MeOH up to 1% as eluent). The desired fractions were collected and concentrated in vacuo to yield intermediate compound D2 (9.2 g, 83%).

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas gradually warmed to r.t.
  3. stirringstirred for 1 h
  4. customquenched with NH4Cl (aqueous sat. solution)
  5. additiondiluted with H2O
  6. extractionThe resulting mixture was extracted with Et2O
  7. customThe organic layer was separated
  8. dry with materialdried (Na2SO4)
  9. concentrationconcentrated in vacuo
  10. customThe crude product was purified by column chromatography (silica gel; DCM/7M solution of NH3 in MeOH up to 1% as eluent)
  11. customThe desired fractions were collected
  12. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-a31f24d3298e4d7087c3468086ffbba5
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085577B2

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