Dimethylformamide → HCID 74397972, 화합물

HRID 1526289

반응식

HRID 1526289 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:14])[CH2:10][C:11](=[O:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].[CH3:21][N:22]([CH3:25])[CH:23]=O.COC(OC)N(C)C>O>[CH3:21][N:22]([CH:25]=[C:10]([C:11](=[O:13])[CH3:12])[C:9]([NH:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])=[O:14])[CH3:23]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 71542'-MethylacetoacetanilideHCID 11430Potassium CarbonateHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 74397972HCID 74397972, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of N-(2-methylphenyl)-3-oxobutanamide (10.0 g), potassium carbonate (7.23 g) and N,N-dimethylformamide (130 mL) was added dropwise 1,1-dimethoxy-N,N-dimethylmethanamine (12.5 g) over 30 min at room temperature, and the reaction mixture was stirred at room temperature for 2 hr. The reaction mixture was slowly poured into water, and the mixture was extracted with dichloromethane. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (10.2 g).

후처리

  1. extractionthe mixture was extracted with dichloromethane
  2. washThe extract was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-423b8b9b926a4ed7bcfb3e0a69db0862
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085578B2

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