[CH:1]([N:5]1[CH:10]=[C:9]([C:11]2[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=2)[C:8](OC)=[C:7]([C:19]#[N:20])[C:6]1=[O:21])([CH2:3][CH3:4])[CH3:2].O.[NH2:23][NH2:24]>C(O)C>[NH2:20][C:19]1[C:7]2[C:6](=[O:21])[N:5]([CH:1]([CH2:3][CH3:4])[CH3:2])[CH:10]=[C:9]([C:11]3[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=3)[C:8]=2[NH:24][N:23]=1To a mixture of 1-(sec-butyl)-4-methoxy-5-(1-methyl-1H-pyrazol-3-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile obtained in Step C (140 mg) and ethanol (5 mL) was added hydrazine monohydrate (122 mg), and the mixture was stirred at 90° C. for 1 hr, cooled to room temperature, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (basic silica gel, ethyl acetate/hexane), and recrystallized from ethyl acetate/diisopropyl ether to give the title compound (82 mg).
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