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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrazine hydrate (1:1) → 3-amino-5-sec-butyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one

HRID 1526379
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HRID 1526379 반응식
[CH:1]([N:5]1[CH:10]=[C:9]([C:11]2[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=2)[C:8](OC)=[C:7]([C:19]#[N:20])[C:6]1=[O:21])([CH2:3][CH3:4])[CH3:2].O.[NH2:23][NH2:24]>C(O)C>[NH2:20][C:19]1[C:7]2[C:6](=[O:21])[N:5]([CH:1]([CH2:3][CH3:4])[CH3:2])[CH:10]=[C:9]([C:11]3[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=3)[C:8]=2[NH:24][N:23]=1
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참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 1177703841-(sec-butyl)-4-methoxy-5-(1-methyl-1H-pyrazol-3-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

생성물 1

HCID 897752093-amino-5-sec-butyl-7-(1-methyl-1H-pyrazol-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-one수율 58.6%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
90 °C

실험 절차

To a mixture of 1-(sec-butyl)-4-methoxy-5-(1-methyl-1H-pyrazol-3-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile obtained in Step C (140 mg) and ethanol (5 mL) was added hydrazine monohydrate (122 mg), and the mixture was stirred at 90° C. for 1 hr, cooled to room temperature, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (basic silica gel, ethyl acetate/hexane), and recrystallized from ethyl acetate/diisopropyl ether to give the title compound (82 mg).

후처리

  1. temperaturecooled to room temperature
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (basic silica gel, ethyl acetate/hexane)
  4. customrecrystallized from ethyl acetate/diisopropyl ether

출처 및 근거

ORD 기록
ord-6426d8159437455fa3fcfc5e51c69cb4
출처 데이터셋
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09085578B2

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