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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Ethylenediamine → (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid ethylenediamine salt hydrate

HRID 1526423
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인쇄 미리보기

반응식

HRID 1526423 반응식
[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH:20]([CH3:22])[CH3:21])=[C:15]([C:23]([F:26])([F:25])[F:24])[CH:14]=3)[CH:7]=[CH:6][C:5]=2[N:4]2[CH2:27][CH2:28][C@H:29]([CH2:30][C:31]([OH:33])=[O:32])[C:3]=12.[CH2:34]([NH2:37])[CH2:35][NH2:36].C(#N)C>C1COCC1>[OH2:11].[CH2:34]([NH2:37])[CH2:35][NH2:36].[Cl:1][C:2]1[C:10]2[CH:9]=[C:8]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH:20]([CH3:22])[CH3:21])=[C:15]([C:23]([F:24])([F:25])[F:26])[CH:14]=3)[CH:7]=[CH:6][C:5]=2[N:4]2[CH2:27][CH2:28][C@H:29]([CH2:30][C:31]([OH:33])=[O:32])[C:3]=12
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 3301EthylenediamineHCID 6342AcetonitrileHCID 53362086(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

생성물 1

HCID 131733173(R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid ethylenediamine salt hydrate

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid (15 mg) was dissolved in THF (0.5 mL) and aqueous ethylenediamine (16 uL, 2.27 M) was added. The homogeneous solution was left to stir at room temperature for 2d. ACN (300 μL) was then added and the reaction was stirred at room temperature for one additional day. The reaction mixture was evaporated to dryness and 0.5 mL of EtOAc was added. After stiffing for 24 h at room temperature, a solid had formed which was collected by filtration. The PXRD pattern of the title compound is shown in FIG. 10; and the DSC and TGA are shown in FIG. 11.

후처리

  1. waitThe homogeneous solution was left
  2. customThe reaction mixture was evaporated to dryness and 0.5 mL of EtOAc
  3. additionwas added
  4. customa solid had formed which
  5. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-573e21a452624ed8acf5f1575512fa33
출처 데이터셋
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09085581B2

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