Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526522노트

반응식

HRID 1526522 반응식
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

참가 물질

4

반응물 2

HCID 313Hydrochloric Acid2회HCID 22024915Icotinib

생성물 1

HCID 44609731Icotinib Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Icotinib (700 mg) and methanol (40 mL) were added into 100 mL of reaction flask, hydrogen chloride gas or concentrated hydrochloric acid was added while stirring. After its completion, the reaction mixture was filtrated to give crude products of Icotinib hydrochloride, which was then purified by recrystallization with isopropanol to give Icotinib hydrochloride (760 mg).

후처리

  1. additionwas added
  2. filtrationAfter its completion, the reaction mixture was filtrated

출처 및 근거

ORD 기록
ord-fff8d148ae044b9fbaad1d3724758ee0
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085588B2

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