Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526523노트

반응식

HRID 1526523 반응식
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>C(O)C>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

생성물 1

HCID 44609731Icotinib Hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Icotinib (500 mg) was added into 100 mL of reaction flask and dissolved with 30 mL of ethanol. Hydrogen chloride gas was added while stirring. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (515 mg).

후처리

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

출처 및 근거

ORD 기록
ord-80da284135314baea98d6d3c9585b5af
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085588B2

반응 노트

불러오는 중…