Hydrochloric Acid → Icotinib Hydrochloride

HRID 1526526노트

반응식

HRID 1526526 반응식
[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[N:19]=[CH:18][N:17]=[C:16]3[C:11]=2[CH:12]=[C:13]2[O:29][CH2:28][CH2:27][O:26][CH2:25][CH2:24][O:23][CH2:22][CH2:21][O:20][C:14]2=[CH:15]3)[CH:8]=1.[ClH:30]>CO>[CH:1]#[C:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([NH:9][C:10]2[C:11]3[C:16](=[CH:15][C:14]4[O:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH2:27][CH2:28][O:29][C:13]=4[CH:12]=3)[N:17]=[CH:18][N:19]=2)[CH:8]=1.[ClH:30]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 22024915Icotinib

생성물 1

HCID 44609731Icotinib Hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Icotinib (1000 mg) was added into 100 mL reaction flask and dissolved with 60 mL of methanol. The concentrated hydrochloric acid was added dropwise while stirring till PH was adjusted to 2.0. After its completion, the reaction mixture was filtered to give crude product. The crude product was further purified by recrystallization with isopropyl alcohol to give Icotinib hydrochloride (1000 mg).

후처리

  1. filtrationAfter its completion, the reaction mixture was filtered
  2. customto give crude product
  3. customThe crude product was further purified by recrystallization with isopropyl alcohol

출처 및 근거

ORD 기록
ord-9e49f2bbef784368a34c6fcfab3981dd
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085588B2

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