Lithium hydroxide, monohydrate → HCID 86673816, 화합물

HRID 1527268노트

반응식

HRID 1527268 반응식
C[O:2][C:3](=[O:17])[CH2:4][C:5]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[C:7]([C:14](=[O:16])[CH3:15])[N:6]=1.O[Li:19].O>C1COCC1.O>[C:14]([C:7]1[N:6]=[C:5]([CH2:4][C:3]([O-:17])=[O:2])[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=12)(=[O:16])[CH3:15].[Li+:19]

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 68283887HCID 68283887, 화합물

생성물 1

HCID 86673816HCID 86673816, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (1-acetyl-imidazo[1,5-a]pyridin-3-yl)-acetic acid methyl ester (1.12 g, 4.82 mmol) in THF (15 mL) and water (7.5 mL) was added LiOH.H2O (202 mg, 4.82 mmol). The reaction was stirred at RT for 5.5 h until completion of the reaction. The mixture was concentrated under reduced pressure and the material thus obtained was used in the next step without further purification: MS (UPLC/MS): 219.2 [M+H]+, 241.2 [M+Na]+, 217.2 [M−H]−; tR (HPLC conditions f): 1.03 min.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe material thus obtained
  3. customwas used in the next step without further purification
  4. custom1.03 min.

출처 및 근거

ORD 기록
ord-4f719a47138746469d7ba26284c64fed
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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