Hydrochloric Acid → 3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzylamine

HRID 1527495노트

반응식

HRID 1527495 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([O:22][CH3:23])[CH2:18][CH2:17]2)[CH:12]=[C:11]([Cl:24])[C:10]=1[F:25])(C)(C)C.Cl>O1CCOCC1>[Cl:24][C:11]1[C:10]([F:25])=[C:9]([CH:14]=[C:13]([CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([O:22][CH3:23])[CH2:18][CH2:17]2)[CH:12]=1)[CH2:8][NH2:7]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68282992[3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester

생성물 1

HCID 710096123-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzylamine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

was prepared according to Scheme C2 (step D) from [3-chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester (225 mg, 0.61 mmol) and 4N HCl in dioxane. MS (LC-MS): 287.0 [M]+; tR (HPLC conditions c): 2.34 min.

후처리

  1. customwas prepared
  2. custom2.34 min.

출처 및 근거

ORD 기록
ord-68cefc90ac1d4467a48c32c399556c18
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

반응 노트

불러오는 중…