Vinylcyclohexene → 3-(2-Cyclohexylethyl)-4,4-dimethylcyclohexanone

HRID 1527836노트

반응식

HRID 1527836 반응식
[CH3:1][C:2]1([CH3:9])[CH2:7][CH2:6][C:5](=[O:8])[CH:4]=[CH:3]1.[CH:10]([C:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]=1)=[CH2:11]>>[CH:12]1([CH2:10][CH2:11][CH:3]2[C:2]([CH3:9])([CH3:1])[CH2:7][CH2:6][C:5](=[O:8])[CH2:4]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

3

반응물 2

HCID 17497VinylcyclohexeneHCID 1368392-Cyclohexen-1-one, 4,4-dimethyl-

생성물 1

HCID 765148593-(2-Cyclohexylethyl)-4,4-dimethylcyclohexanone수율 75%

실험 절차

Using 4,4-dimethylcyclohex-2-enone (53 μL, 0.40 mmol) as substrate and vinylcyclohexene (0.14 mL, 1 mmol, 2.5 eq) as reagent and following General Procedure 3 overnight gave the above product (72 mg, 0.30 mmol, 75%) as a colourless oil after purification by column chromatography (1:49 EtOAc/petrol). The product compound was characterised using 1H NMR and 13C NMR, IR and MS. The presence of an enantioexcess was determined by derivatization using the procedure described in Example 1.

후처리

  1. customGeneral Procedure 3 overnight

출처 및 근거

ORD 기록
ord-22c76dd00819494481b327f9bddc8675
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090545B2

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