Trimethylsilylacetylene → 4-Ethynylisoquinolin-8-amine
반응식
Br[C:2]1[C:11]2[C:6](=[C:7]([NH2:12])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[C:13]([Si](C)(C)C)#[CH:14]>>[C:13]([C:2]1[C:11]2[C:6](=[C:7]([NH2:12])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1)#[CH:14]참가 물질
3
실험 절차
The title compound can be synthesized from 4-ethynylisoquinolin-8-amine and N-(3-iodo-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide in a manner similar to that described for Example 1. 4-ethynylisoquinolin-8-amine is prepared from 4-bromoisoquinolin-8-amine and ethynyltrimethylsilane according to the 2 steps procedure described in example 1.
출처 및 근거
- ORD 기록
- ord-7055c23bab7c4ddc819b29a9cb50f9dd
- 출처 데이터셋
- uspto-grants-2015_07
- 특허 번호
- US09090561B2
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