Dimethylformamide dimethyl acetal → HCID 86686550, 화합물

HRID 1528058노트

반응식

HRID 1528058 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[NH:22][N:23]=[C:24]([C:29](=[O:33])[CH2:30][O:31][CH3:32])[C:25]([O:27][CH3:28])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34]OC(OC)N(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([N:15]2[CH:19]=[C:18]([F:20])[C:17]([F:21])=[CH:16]2)[CH:12]=[CH:11][C:10]=1[N:22]1[CH:34]=[C:30]([O:31][CH3:32])[C:29](=[O:33])[C:24]([C:25]([O:27][CH3:28])=[O:26])=[N:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 178496279HCID 178496279, 화합물

생성물 1

HCID 86686550HCID 86686550, 화합물

실험 절차

A mixture of methyl 2-{[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]hydrazono}-4-methoxy-3-oxobutanoate (4.85 g) and N,N-dimethylformamide dimethyl acetal (100 mL) was heated under reflux for 3 hr. The mixture was allowed to be cooled to room temperature, and the precipitate was collected by filtration, and recrystallized from methanol to give the title compound (4.57 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-73e61775898445eab5cf791643266ed4
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090586B2

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