Methanol → 1-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acid

HRID 1529036노트

반응식

HRID 1529036 반응식
[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2([C:10]#N)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[OH-:14].[Na+].C[OH:17]>>[Br:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][C:7]2([C:10]([OH:17])=[O:14])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 66578489HCID 66578489, 화합물

생성물 1

HCID 658114561-[(4-Bromophenyl)methyl]cyclopropanecarboxylic acid

실험 절차

1-(4-Bromo-benzyl)-cyclopropanecarbonitrile (from the previous step) was dissolved in MeOH and NaOH (35% aq.) and the reaction was heated to reflux for 8 hours. After cooling the reaction was submitted to standard acid-base workup to afford the title compound.

후처리

  1. temperatureto reflux for 8 hours
  2. temperatureAfter cooling the reaction

출처 및 근거

ORD 기록
ord-d6fa3e0e3dc248e0966074ae4b52bb24
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090573B2

반응 노트

불러오는 중…