Lithium Hydroxide → (R)-3-Benzylsulfanyl-2-hydroxy-propionic acid

HRID 15292

반응식

HRID 15292 반응식
C[O:2][C:3](=[O:15])[C@@H:4]([OH:14])[CH2:5][S:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Li+]>>[CH2:7]([S:6][CH2:5][C@H:4]([OH:14])[C:3]([OH:15])=[O:2])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 3939Lithium HydroxideHCID 59639322(R)-3-Benzylsulfanyl-2-hydroxy-propionic acid methyl ester

생성물 1

HCID 10059030(R)-3-Benzylsulfanyl-2-hydroxy-propionic acid수율 46%

실험 절차

This reaction was performed as previously described by Deechongkit, S.; You, S.-L.; Kelly, J. W. Org. Lett. 2004, 6, 497, using (R)-3-Benzylsulfanyl-2-hydroxy-propionic acid methyl ester 110b and lithium hydroxide. (R)-3-Benzylsulfanyl-2-hydroxy-propionic acid 110c (3.08 g, 14.51 mmol, 46%) was isolated as a viscous oil: MS calcd. for C10H12O3S (M+Na+) 235.1, found 235.3.

출처 및 근거

ORD 기록
ord-f2fcc4ac494d4576aa69fc15fbe1ce49
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732449B2

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