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Hydrochloric Acid → 1-(5-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyridin-3-yl)piperidin-4-amine

HRID 1529351
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HRID 1529351 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14](C1CCCCO1)[N:13]=[C:12]2[C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][CH:33]([NH:36]C(=O)OC(C)(C)C)[CH2:32][CH2:31]2)[CH:27]=[N:28][CH:29]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][N:13]=[C:12]2[C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32][CH2:31]2)[CH:27]=[N:28][CH:29]=1
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67960050tert-butyl 1-(5-(5-(2,6-difluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyridin-3-yl)piperidin-4-ylcarbamate

생성물 1

HCID 679599621-(5-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyridin-3-yl)piperidin-4-amine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
85 °C

실험 절차

A solution of tert-butyl 1-(5-(5-(2,6-difluorophenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-3-yl)pyridin-3-yl)piperidin-4-ylcarbamate (120 mg, 0.204 mmol) in dioxane (5 mL) was treated with concentrated HCl (0.113 mL, 2.035 mmol). The reaction was heated to 85° C. After 1 h, the reaction was cooled to 23° C. and concentrated. The residue (as HCl salt) was free-based using a Silicycle Si-propylsulfonic acid ion exchange column (catalog # R51230B). The compound was diluted in MeOH and added to a pad of the resin (wetted and flushed with 10 mL MeOH). It was flushed with MeOH (50 mL), and then the product was “released” using 2.0 M NH3 in MeOH solution (50 ml). The final filtrate was concentrated, affording 1-(5-(5-(2,6-difluorophenyl)-1H-indazol-3-yl)pyridin-3-yl)piperidin-4-amine. MS (ESI, pos. ion) m/z: 406.2 (M+1).

후처리

  1. temperaturethe reaction was cooled to 23° C.
  2. concentrationconcentrated
  3. additionThe compound was diluted in MeOH
  4. additionadded to a pad of the resin (wetted and flushed with 10 mL MeOH)
  5. customIt was flushed with MeOH (50 mL)
  6. concentrationThe final filtrate was concentrated

출처 및 근거

ORD 기록
ord-2b51d7bcd5db4d02b276bf4bfb3a1f71
출처 데이터셋
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09090593B2

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