홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Hydroxide → tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate

HRID 1529419
노트
인쇄 미리보기

반응식

HRID 1529419 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14](S(C1C=CC(C)=CC=1)(=O)=O)[CH:13]=[C:12]2[C:28]1[CH:33]=[C:32]([O:34][CH3:35])[N:31]=[C:30]([N:36]2[CH2:41][CH2:40][CH:39]([NH:42][C:43](=[O:49])[O:44][C:45]([CH3:48])([CH3:47])[CH3:46])[CH2:38][CH2:37]2)[N:29]=1.[OH-].[Na+]>O1CCOCC1>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[C:28]1[CH:33]=[C:32]([O:34][CH3:35])[N:31]=[C:30]([N:36]2[CH2:41][CH2:40][CH:39]([NH:42][C:43](=[O:49])[O:44][C:45]([CH3:47])([CH3:46])[CH3:48])[CH2:38][CH2:37]2)[N:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86709789tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1-tosyl-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate

생성물 1

HCID 67976781tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate수율 54%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1-tosyl-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate (60 mg, 0.087 mmol) in dioxane (0.8 mL) was added 7M aq.NaOH (1 mL) and the mixture was heated at 90° C. for 6 h. The reaction was quenched with water and the suspension was filtered. The resulting solid was washed with water and dried. The crude was purified with basic alumina chromatography to give tert-butyl (1-(4-(5-(2,6-difluorophenyl)-1H-indol-3-yl)-6-methoxypyrimidin-2-yl)piperidin-4-yl)carbamate (25 mg, 54%). 1H-NMR (300 MHz, DMSO-d6): δ 11.80 (brs, 1H), 8.58 (s, 1H), 8.26 (s, 1H), 7.40-7.55 (m, 2H), 7.18-7.26 (m, 4H), 6.85 (d, J=7.5 Hz, 1H) 6.49 (s, 1H), 4.66 (d, J=11.7 Hz, 2H), 3.84 (s, 3H), 3.52 (brs, 2H), 2.97-3.05 (m, 2H), 1.7 (brs, 2H), 1.38 (s, 9H).

후처리

  1. customThe reaction was quenched with water
  2. filtrationthe suspension was filtered
  3. washThe resulting solid was washed with water
  4. customdried
  5. customThe crude was purified with basic alumina chromatography

출처 및 근거

ORD 기록
ord-6ca24a7f13534057b8f29f013ef7b1db
출처 데이터셋
uspto-grants-2015_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09090593B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트