HCID 54173602, 화합물 → HCID 13885606, 화합물

HRID 1530748노트

반응식

HRID 1530748 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH:16]=[C:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18]([F:21])([F:20])[F:19])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][CH2:16][CH:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18]([F:19])([F:20])[F:21])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 54173602HCID 54173602, 화합물HCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 13885606HCID 13885606, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

4-(3-Phenoxyphenyl)-1-phenyl-1-trifluoromethyl-1-butene (3.18 g; 8.6 mmol) was hydrogenated in ethanol (40 ml) with hydrogen with the addition of Raney nickel (0.4 g) at room temperature and under atmospheric pressures. After the calculated amount of hydrogen had been taken up, the catalyst was filtered off and the solvent removed under reduced pressure. After chromatography on silica gel with hexane/toluene, there remained 2.49 g of product (=78% of theory).

후처리

  1. filtrationthe catalyst was filtered off
  2. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-30298c6f27244d23a3949a9eb7a69afe
출처 데이터셋
uspto-grants-2001_03
특허 번호
USRE037087E1

반응 노트

불러오는 중…