Sodium cyanoborohydride → HCID 15524191, 화합물

HRID 1530839노트

반응식

HRID 1530839 반응식
Cl.[Br:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH2:16])=[C:9]2[C:4]=1[CH2:5][CH2:6]N[CH2:8]2.[C:17]([BH3-])#[N:18].[Na+]>CO.O>[Br:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[C:10]([NH2:16])=[C:9]2[C:4]=1[CH2:5][CH2:6][N:18]([CH2:17][CH2:5][C:4]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:3]=1)[CH2:8]2

참가 물질

4

반응물 2

HCID 5003444Sodium cyanoborohydrideHCID 21253084HCID 21253084, 화합물

생성물 1

HCID 15524191HCID 15524191, 화합물수율 190.3%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

A solution of the product from Example 5 (1 g, 3.24 mmol) and phenylacetylaldehyde (0.82 ml, 7 mmol) in 2:1 MeOH/H2O (50 mL) was treated with sodium cyanoborohydride (0.56 g, 9 mmol) portionwise under nitrogen and stirred for one hour. The reaction mixture was then cooled under an ice bath and precipitate filtered off. The solids were washed with hexane and oven dried to give the title compound (1.16 g, 95% yield) as an orange solid, mp=120-122° C.

후처리

  1. temperatureThe reaction mixture was then cooled under an ice bath
  2. filtrationprecipitate filtered off
  3. washThe solids were washed with hexane and oven
  4. customdried

출처 및 근거

ORD 기록
ord-4619477b2c754902913931b33673d084
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197771B1

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