Sodium borohydride → (7r,8r,9r)-3-Hydroxymethyl-7,8-dihydroxy-2-methyl-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine
반응식
[CH:1]([C:3]1[N:7]2[CH:8]=[CH:9][C:10]3[C:11](=[O:23])[C@H:12]([OH:22])[C@@H:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[NH:14][C:15]=3[C:6]2=[N:5][C:4]=1[CH3:24])=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[N:7]2[CH:8]=[CH:9][C:10]3[C@@H:11]([OH:23])[C@H:12]([OH:22])[C@@H:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[NH:14][C:15]=3[C:6]2=[N:5][C:4]=1[CH3:24]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
0.07 g of (8R,9R)-3-formyl-8-hydroxy-2-methyl-7-oxo-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine are dissolved in 5 ml of dry methanol, and 0.1 g of sodium borohydride is added. The mixture is stirred for 30 min and concentrated in vacuo. The oily residue is partitioned between water and chloroform. The organic layer is separated, dried over anhydrous sodium sulfate and concentrated. The product is purified by flash chromatography on silica gel (eluent: dichloromethane/methanol 9/1) to give 0.05 g of the title compound as a semi solid.