Sodium Hydroxide → N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

HRID 1531954노트

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HRID 1531954 반응식
C([N:4]1[C:12]2[C:7](=[C:8]([CH3:25])[C:9]([CH2:21][N:22]([CH3:24])[CH3:23])=[C:10]([CH3:20])[C:11]=2[NH:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>CO.O>[CH3:23][N:22]([CH2:21][C:9]1[C:8]([CH3:25])=[C:7]2[C:12](=[C:11]([NH:13][C:14](=[O:19])[C:15]([CH3:16])([CH3:17])[CH3:18])[C:10]=1[CH3:20])[NH:4][CH2:5][CH2:6]2)[CH3:24]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22247311N-(1-Acetyl-5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

생성물 1

HCID 22247324N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide수율 79.7%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

N-(1-Acetyl-5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide (1.0 g) was dissolved in MeOH (10 ml) and a solution of NaOH (580 mg) in water (3 ml) was added, which was followed by stirring at 60° C. for 2 hr. MeOH was evaporated under reduced pressure and CHCl3 (100 ml) was added. The mixture was washed with saturated brine and dried over anhydrous sodium sulfate. CHCl3 was evaporated under reduced pressure to give 700 mg of N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide.

후처리

  1. customMeOH was evaporated under reduced pressure and CHCl3 (100 ml)
  2. additionwas added
  3. washThe mixture was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customCHCl3 was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3751c49b9e6f44acb7e7cb73f4b96791
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06200988B1

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