Alpha-Cyclodextrin → (+)-Lactose

HRID 1532584노트

반응식

HRID 1532584 반응식
C([O-])(=O)C(CCC)CCC.[Na+].[CH2:12]([OH:77])[C@H:13]1[O:18][C@@H:17]2[O:19][C@H:20]3[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]4[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]5[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]6[C@H:52]([OH:53])[C@@H:51]([OH:54])[C@@H:50]([O:55][C@H:56]7[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]1[C@H:15]([OH:76])[C@H:16]2[OH:75])[O:58][C@@H:57]7[CH2:65][OH:66])[O:49][C@@H:48]6[CH2:67][OH:68])[O:40][C@@H:39]5[CH2:69][OH:70])[O:31][C@@H:30]4[CH2:71][OH:72])[O:22][C@@H:21]3[CH2:73][OH:74]>O>[OH:19][CH:17]1[O:18][C@H:13]([CH2:12][OH:77])[C@@H:14]([O:60][C@@H:59]2[O:58][C@H:57]([CH2:65][OH:66])[C@H:56]([OH:55])[C@H:62]([OH:63])[C@H:61]2[OH:64])[C@H:15]([OH:76])[C@H:16]1[OH:75].[CH2:67]([OH:68])[C@H:48]1[O:49][C@@H:50]2[O:55][C@H:56]3[C@H:62]([OH:63])[C@@H:61]([OH:64])[C@@H:59]([O:60][C@H:14]4[C@H:15]([OH:76])[C@@H:16]([OH:75])[C@@H:17]([O:19][C@H:20]5[C@H:25]([OH:26])[C@@H:24]([OH:27])[C@@H:23]([O:28][C@H:29]6[C@H:34]([OH:35])[C@@H:33]([OH:36])[C@@H:32]([O:37][C@H:38]7[C@H:43]([OH:44])[C@@H:42]([OH:45])[C@@H:41]([O:46][C@H:47]1[C@H:52]([OH:53])[C@H:51]2[OH:54])[O:40][C@@H:39]7[CH2:69][OH:70])[O:31][C@@H:30]6[CH2:71][OH:72])[O:22][C@@H:21]5[CH2:73][OH:74])[O:18][C@@H:13]4[CH2:12][OH:77])[O:58][C@@H:57]3[CH2:65][OH:66]

참가 물질

5

반응물 2

HCID 444913Alpha-CyclodextrinHCID 16760703Sodium valproate

생성물 2

HCID 440995(+)-LactoseHCID 444913Alpha-Cyclodextrin

시약·촉매·용매 1

HCID 962Water용매

실험 절차

166 g (1 mole) sodium valproate and 90 g (moisture content<5%, 0.09 mole) a α-cyclodextrin are blended and 20 mL water is added. The ingredients are thoroughly kneaded, and the product is obtained by drying and grinding as described in Example 1. The moisture absorption after 24 hour storage at 40° C. under 75% relative humidity was found to be 43%, compared to 70% and 47% of sodium valproate itself and of the product obtained in a similar way with lactose instead of a α-cyclodextrin, respectively. The latter two were liquified.

후처리

  1. customthe product is obtained
  2. customby drying
  3. customgrinding
  4. customThe moisture absorption after 24 hour storage at 40° C. under 75% relative humidity

출처 및 근거

ORD 기록
ord-6f30f466fc1f4d8ea80dd3343d197fba
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06204255B1

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