Hydrochloric Acid → Viloxazine Hydrochloride

HRID 1532984노트

반응식

HRID 1532984 반응식
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH2:23][CH3:24])[CH2:9]1)C1C=CC=CC=1.[ClH:25]>C(O)C.[Pd]>[ClH:25].[CH2:23]([O:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1)[CH3:24]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 12297772Morpholine, 2-[(2-ethoxyphenoxy)methyl]-4-(phenylmethyl)-

생성물 1

HCID 71424Viloxazine Hydrochloride수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The title compound was prepared by hydrogenation of (±)-4-benzyl-2-[(2-ethoxyphenoxy)-methyl]morpholine over 5% Pd/C in ethanol: 1 M aqueous HCl 3:1. mp 176-179° C. Yield 96%.

출처 및 근거

ORD 기록
ord-61fa7fb9104b4d309a32f21e50739f69
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06207662B1

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