Water → Furo[2,3-c]pyridin-5-ylmethanol

HRID 15330노트

반응식

HRID 15330 반응식
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]2[CH:14]=[CH:13][O:12][C:9]2=[CH:10][N:11]=1)(=O)C.O.[OH-].[Na+]>O1CCOCC1>[O:12]1[C:9]2=[CH:10][N:11]=[C:6]([CH2:5][OH:4])[CH:7]=[C:8]2[CH:14]=[CH:13]1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22047292HCID 22047292, 화합물

생성물 1

HCID 22047174Furo[2,3-c]pyridin-5-ylmethanol수율 70.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Also to yield the desired compound: Furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g, 6 mmol) was dissolved in 1,4-dioxane (30 ml) and water (10 ml) and treated with 2N sodium hydroxide solution (12 ml) and stirred at RT for 18 h. The mixture was then partitioned between ethyl acetate and water, the organic layer was dried and evaporated to dryness to provide the desired compound (0.63 g).

후처리

  1. customThe mixture was then partitioned between ethyl acetate and water
  2. customthe organic layer was dried
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-adde202e72824f69a5298fe6bf9019ec
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732461B2

반응 노트

불러오는 중…