Hydrochloric Acid → Methyl (1,2-benzoxazol-3-yl)acetate

HRID 1533013노트

반응식

HRID 1533013 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]COCC.Cl>CO>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 3017292-(1,2-Benzoxazol-3-yl)acetic acid

생성물 1

HCID 2763403Methyl (1,2-benzoxazol-3-yl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1,2-benzisoxazole-3-acetic acid (prepared according to G. Casini et al, J. Het. Chem. 6, 1969, 279) (18 g), ether saturated with dry HCl (150 ml) and methanol (200 ml) was stirred for 2 h at room temperature. Removal of the volatiles in vacuo gave methyl 1 ,2-benzisoxazole-3-acetate (17 g) as an oil. The oil was dissolved in tetrahydrofuran (100 ml) and added dropwise to a suspension of lithium aluminium hydride (6 g) in tetrahydrofuran (200 ml) at 0-10° C. followed by stirring for 30 min at 15° C. Usual work-up gave 2-(1 ,2-benzisoxazol-3-yl)ethanol (13 g) as an oil.

후처리

  1. customRemoval of the volatiles in vacuo

출처 및 근거

ORD 기록
ord-d617c80cd00c42ca844004d2d4805f0a
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06207677B1

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