Sodium Hydroxide → 3-tert-Butyl-4-hydroxybenzoic acid

HRID 1534308노트

반응식

HRID 1534308 반응식
C([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[C:14]([CH3:17])([CH3:16])[CH3:15])(=O)C.[OH-].[Na+]>CO.O>[C:14]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:5]=1[OH:4])[C:9]([OH:11])=[O:10])([CH3:17])([CH3:15])[CH3:16]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 180077364-(Acetyloxy)-3-tert-butylbenzoic acid

생성물 1

HCID 144015103-tert-Butyl-4-hydroxybenzoic acid수율 98.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

50.0 g of 4-acetoxy-3-tert-butylbenzoic acid are dissolved in 200 g of methanol. A solution of 10.2 g of sodium hydroxide in 180 ml of water is added. The mixture is refluxed for 3 hours. The methanol is removed, and the mixture is acidified with hydrochloric acid (10%) at 10° C. The precipitate is filtered off and washed, giving 40.6 g of product in the form of colourless crystals having a melting point of from 158° to 159° C.

후처리

  1. temperatureThe mixture is refluxed for 3 hours
  2. customThe methanol is removed
  3. customis acidified with hydrochloric acid (10%) at 10° C
  4. filtrationThe precipitate is filtered off
  5. washwashed

출처 및 근거

ORD 기록
ord-66f3d6dc3e8844098280cc63de608c14
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05089050

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