Methanol → Quizalofop

HRID 1534310

반응식

HRID 1534310 반응식
CO.[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14][C:15]1[CH:27]=[CH:26][C:18]([O:19][CH:20]([CH3:25])[C:21]([O:23]C)=[O:22])=[CH:17][CH:16]=1)[CH:8]=[N:7]2.[OH-].[Na+]>O1CCCC1>[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[C:9]([O:14][C:15]1[CH:16]=[CH:17][C:18]([O:19][CH:20]([CH3:25])[C:21]([OH:23])=[O:22])=[CH:26][CH:27]=1)[CH:8]=[N:7]2

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 187101Quizalofop-methyl

생성물 1

HCID 178795Quizalofop수율 76.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Into a mixture of methanol (10 ml) and tetrahydrofuran (14 ml), methyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionate (0.6 g) was dissolved, and lN sodium hydroxide solution (2.5 ml) was added thereto. The reaction was carried out at room temperature while stirring for 2 hours. After removal of methanol and tetrahydrofuran by distillation, the aqueous layer was washed with dichloromethane (1 ml), made acidic with conc. hydrochloric acid and extracted with ethyl acetate. The extract was concentrated to remove ethyl acetate to give 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propionic acid (0.44 g). Yield, 76%.

후처리

  1. dissolutionwas dissolved
  2. customwas carried out at room temperature
  3. customAfter removal of methanol and tetrahydrofuran
  4. distillationby distillation
  5. washthe aqueous layer was washed with dichloromethane (1 ml)
  6. extractionextracted with ethyl acetate
  7. concentrationThe extract was concentrated
  8. customto remove ethyl acetate

출처 및 근거

ORD 기록
ord-f86923cfcf2f4d39857ee1f34d5789d9
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05089043

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