Pyrrolidine → HCID 15165792, 화합물

HRID 1534447노트

반응식

HRID 1534447 반응식
Cl.CO[C:4](=[O:13])[CH:5]1[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][NH:6]1.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>>[N:14]1([C:4]([CH:5]2[CH2:10][CH2:9][C:8]([CH3:11])([CH3:12])[CH2:7][NH:6]2)=[O:13])[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 67791332129769-06-8

생성물 1

HCID 15165792HCID 15165792, 화합물

실험 절차

4.2 g (23.5 mmoles) of 5,5-dimethyl pipecolic acid methyl ester hydrochloride were added to 40 ml of pyrrolidine kept at 0° C. After the addition, the solution was allowed to reach room temperature and stirring was continued overnight. The reaction mixture was evaporated in vacuo and the residue treated with 30 ml of 40% NaOH, extracted with diethyl ether, dried over sodium sulphate and evaporated in vacuo to dryness to give 3.3 g of the title compound.

후처리

  1. customkept at 0° C
  2. additionAfter the addition
  3. customto reach room temperature
  4. customThe reaction mixture was evaporated in vacuo
  5. additionthe residue treated with 30 ml of 40% NaOH
  6. extractionextracted with diethyl ether
  7. dry with materialdried over sodium sulphate
  8. customevaporated in vacuo to dryness

출처 및 근거

ORD 기록
ord-8f11a589412746c98a70e2e1ff6f35e9
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05089507

반응 노트

불러오는 중…