P-Toluenesulfonamide → 2,5-Ditosyl-1,2,3,4,5,6-hexahydropyrrolo[3,4-c]pyrrole

반응식

Br[CH2:2][C:3]([CH2:9]Br)=[C:4]([CH2:7]Br)[CH2:5]Br.[CH3:11][C:12]1[CH:13]=[CH:14][C:15]([S:18]([NH2:21])(=[O:20])=[O:19])=[CH:16][CH:17]=1.[H-].[Na+]>CN(C)C=O>[C:12]1([CH3:11])[CH:13]=[CH:14][C:15]([S:18]([N:21]2[CH2:7][C:4]3[CH2:5][N:21]([S:18]([C:15]4[CH:16]=[CH:17][C:12]([CH3:11])=[CH:13][CH:14]=4)(=[O:19])=[O:20])[CH2:9][C:3]=3[CH2:2]2)(=[O:20])=[O:19])=[CH:16][CH:17]=1

참가 물질

실험 절차

30 g of tetrakis (bromomethyl)ethylene and 30 g of p-toluene sulfonamide were dissolved in 400 ml of dimethylformamide. 150 g of potassium carbonate anhydride (or 50% sodium hydride 17 g) was added and then stirred at room temperature for 24 hours. Thereafter, this reaction mixture was distilled under vacuum to remove solvents. By adding 30 ml of water and 100 ml of ethylacetate, 17 g of the title compound was obtained as pale yellow powder (yield 50%).