Methyl Thioglycolate → Methyl 7-chlorobenzo[b]thiophene-2-carboxylate

HRID 15434

반응식

HRID 15434 반응식
F[C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[H-].[Na+].[SH:13][CH2:14][C:15]([O:17][CH3:18])=[O:16]>>[CH3:18][O:17][C:15]([C:14]1[S:13][C:2]2[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=1)=[O:16]

참가 물질

4

반응물 3

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 7363353-Chloro-2-fluorobenzaldehyde

생성물 1

HCID 22474203Methyl 7-chlorobenzo[b]thiophene-2-carboxylate

실험 절차

Using 1.0 g (6.31 mmol) of 2-fluoro-3-chlorobenzaldehyde, 0.38 g (9.46 mmol) of sodium hydride (60% pure) and 0.74 g (6.94 mmol) of methyl mercaptoacetate, 1.04 g (72.3% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-92624d1e680540a998df40eb5b5b9df9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732477B2

연결된 노트

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