Methyl Thioglycolate → 5,7-Difluoro-benzo[B]thiophene-2-carboxylic acid methyl ester

HRID 15437노트

반응식

HRID 15437 반응식
F[C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=1[CH:4]=O.[H-].[Na+].[SH:14][CH2:15][C:16]([O:18][CH3:19])=[O:17]>>[CH3:19][O:18][C:16]([C:15]1[S:14][C:2]2[C:9]([F:10])=[CH:8][C:7]([F:11])=[CH:6][C:3]=2[CH:4]=1)=[O:17]

참가 물질

4

반응물 3

HCID 16907Methyl ThioglycolateHCID 24758Sodium hydrideHCID 27769502,3,5-Trifluorobenzaldehyde

생성물 1

HCID 573508905,7-Difluoro-benzo[B]thiophene-2-carboxylic acid methyl ester

실험 절차

Using 3.94 g (24.6 mmol) of 2,3,5-trifluorobenzaldehyde, 1.48 g (36.9 mmol) of sodium hydride (60% pure) and 2.88 g (27.1 mmol) of methyl mercaptoacetate, 3.58 g (56% of theory) of the title compound are obtained in a purity of 89%. Recrystallization from methanol gives the product in a purity of 97%.

출처 및 근거

ORD 기록
ord-19b42af1a5f8419ea1724dae2f63a164
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732477B2

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