Diethyl Ether → tert-butyl 4-(1-(4-chlorophenyl)-2-(thiazol-2-yl)ethylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

HRID 1544722노트

반응식

[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[NH:32][C:33]1([C:48](=[O:49])[OH:50])[CH2:34][CH2:35][N:36]([c:39]2[c:40]3[c:41]([n:42][cH:43][n:44]2)[nH:45][cH:46][cH:47]3)[CH2:37][CH2:38]1.[CH3:75][N:76]1[CH2:77][CH2:78][CH2:79][C:80]1=[O:81].[CH3:82][CH2:83][O:84][CH2:85][CH3:86].[CH:66]([N:67]([CH2:68][CH3:69])[CH:70]([CH3:71])[CH3:72])([CH3:73])[CH3:74].[Cl:51][c:52]1[cH:53][cH:54][c:55]([CH:58]([CH2:59][c:60]2[s:61][cH:62][cH:63][n:64]2)[NH2:65])[cH:56][cH:57]1.[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[NH:32][C:33]1([C:48](=[O:50])[NH:65][CH:58]([c:55]2[cH:54][cH:53][c:52]([Cl:51])[cH:57][cH:56]2)[CH2:59][c:60]2[s:61][cH:62][cH:63][n:64]2)[CH2:34][CH2:35][N:36]([c:39]2[c:40]3[c:41]([n:42][cH:43][n:44]2)[nH:45][cH:46][cH:47]3)[CH2:37][CH2:38]1