Hydrochloric Acid → (RS)-1-[2-(3-Chloro-furo[3,2-b]pyridin-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone

HRID 1547847노트

반응식

[Cl:1].[Cl:33][CH2:34][Cl:35].[F:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[c:10]([C:15](=[O:16])[N:17]3[CH:18]([CH2:23][c:24]4[cH:25][c:26]5[n:27][cH:28][cH:29][cH:30][c:31]5[o:32]4)[CH2:19][CH2:20][CH2:21][CH2:22]3)[n:11][c:12]([CH3:14])[s:13]2)[cH:7][cH:8]1>>[F:2][c:3]1[cH:4][cH:5][c:6](-[c:9]2[c:10]([C:15](=[O:16])[N:17]3[CH:18]([CH2:23][c:24]4[c:25]([Cl:33])[c:26]5[n:27][cH:28][cH:29][cH:30][c:31]5[o:32]4)[CH2:19][CH2:20][CH2:21][CH2:22]3)[n:11][c:12]([CH3:14])[s:13]2)[cH:7][cH:8]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 6344Dichloromethane

HCID 23146339(RS)-1-[5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-1-(2-furo [3,2-b]-pyridin-2-ylmethyl-piperidin-1-yl)methanone

생성물 1

HCID 23146311(RS)-1-[2-(3-Chloro-furo[3,2-b]pyridin-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-methyl-thiazol-4-yl]-methanone

출처 및 근거

ORD 기록: ord-76605c9383054180bde85d91117f99ba
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

반응 노트

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