Sodium Bicarbonate → (3,3-Diethoxy-propyl)-carbamic acid allyl ester

HRID 15529

반응식

HRID 15529 반응식
[C:1](Cl)(=[O:5])[CH2:2][CH:3]=C.[CH2:7]([O:9][CH:10]([O:14][CH2:15][CH3:16])[CH2:11][CH2:12][NH2:13])[CH3:8].[C:17]([O-])(O)=[O:18].[Na+]>C(Cl)Cl>[CH2:2]([O:3][C:17](=[O:18])[NH:13][CH2:12][CH2:11][CH:10]([O:14][CH2:15][CH3:16])[O:9][CH2:7][CH3:8])[CH:1]=[CH2:5]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 5210291-Amino-3,3-diethoxypropaneHCID 10975427But-3-enoyl Chloride

생성물 1

HCID 86605042(3,3-Diethoxy-propyl)-carbamic acid allyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

But-3-enoyl chloride (930 uL, 8.84 mmol) was added slowly to a rapidly stirring mixture of 3,3-diethoxy-propylamine (1.0 g, 6.80 mmol) and NaHCO3 (2 mL of 0.6 M NaHCO3 in water) in DCM (100 mL). The reaction was stirred at room temperature overnight, then partitioned between water and DCM. The organic layer was washed several times with water and concentrated to give the crude sub-title compound that was used without further purification.

후처리

  1. stirringThe reaction was stirred at room temperature overnight
  2. custompartitioned between water and DCM
  3. washThe organic layer was washed several times with water
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-233d52f44e6349a7a7bc1dd57e6b77de
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732618B2

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