Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 15574생성일: 2026년 10월 26일
Sodium Bicarbonate → (4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester
https://huagongshe.com/reaction/15574
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| 반응물 | Tert-butyl 4-fluoro-3-nitrophenylcarbamate | HCID 11118665 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | (4-tert-Butoxycarbonylamino-2-nitro-phenylamino)-acetic acid tert-butyl ester | HCID 67201113 | — |
반응 단계
Glycine tert-butyl ester hydrochloride (4.1 g, 29.4 mmol) and NaHCO3 (5.1 g, 61.0 mmol) were added to a solution of (4-fluoro-3-nitro-phenyl)-carbamic acid tert-butyl ester (5.2 g, 20.3 mmol) in DMSO (16 mL). The reaction was heated to 65° C. for 5 hours, cooled to room temperature, and partitioned between H2O and EtOAc. The organic layer was washed several times with H2O and concentrated to afford the sub-title compound. MS calculated for C17H25N3O6+H: 368, observed: 368.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732618B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-d34867f288344e0b81e93b133d1f1951 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
