Hydrazine hydrate (1:1) → 6-Phenyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

HRID 15723노트

반응식

HRID 15723 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][C:12](=[CH:14]O)[C:11](=O)[CH2:10][CH:9]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:24][NH2:25]>CO>[C:1]([O:5][C:6]([N:8]1[CH:9]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:10][C:11]2[NH:24][N:25]=[CH:14][C:12]=2[CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 685032875-Hydroxymethylene-4-oxo-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 593424006-Phenyl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Compound 51 (310 mg, 1.02 mmol) from the previous step was dissolved in MeOH (3 ml). Hydrazine monohydrate (0.1 ml, 2.04 mmol) was added to the solution and then stirred at room temperature for 1 hour. Solvent was removed under reduced pressure to afford a yellow gel as the desired product. LCMS 300.2 (M+1)

후처리

  1. customSolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5cb7788b0c2a435e9b5881cb3ca4164c
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732609B2

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