5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine

HRID 1573

반응식

HRID 1573 반응식
C([C:3]1[C:4](=[O:16])[NH:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[CH:8]=1)#N>OP(O)(O)=O>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:7]2[CH:8]=[CH:3][C:4](=[O:16])[NH:5][CH:6]=2)=[CH:14][CH:13]=1

참가 물질

3

반응물 1

HCID 27639105-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

생성물 1

HCID 102623725-(4-Chlorophenyl)-2-hydroxypyridine수율 75.6%

시약·촉매·용매 1

HCID 1004Phosphoric Acid용매

실험 절차

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-1a4f37788b1a484282d9cf4c25552db7
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726176

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