O1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.F[C:10](F)(F)[C:11](OC(=O)C(F)(F)F)=O.Cl.[NH2:23][C:24]1[NH:25][CH:26]=[CH:27][N:28]=1>O1CCCC1.C(N(CC)CC)C>[C:3]1([C:6]([NH:23][C:24]2[NH:25][CH:26]=[CH:27][N:28]=2)=[O:8])[CH:4]=[CH:5][CH:11]=[CH:10][CH:2]=1To a solution of 3-furoic acid in 50 ml. of tetrahydrofuran, there is added 10.5 g. of trifluoroacetic anhydride. To the resulting solution, after 30 minutes and at 20°-25°C., there is added 15 ml. of triethylamine and 4.1 g. of 2-aminoimidazole hydrochloride and 20 ml. of tetrahydrofuran. The thus-obtained reaction mixture is allowed to stand overnight at 20° -25°C., followed by concentration, dilution with water, filtration and recrystallization from methanol to yield 2-(3-furylcarbonylamino)-imidazole [(III), R = 3-furyl], identical to that obtained in Example 1A.
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