Pyridine → Cyclohexanone, 4-[(acetyloxy)methyl]-4-(4-chlorophenyl)-

HRID 1576217노트

반응식

HRID 1576217 반응식
[OH:1][CH2:2][C:3]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.N1C=CC=CC=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>O>[C:23]([O:1][CH2:2][C:3]1([C:10]2[CH:11]=[CH:12][C:13]([Cl:16])=[CH:14][CH:15]=2)[CH2:4][CH2:5][C:6](=[O:9])[CH2:7][CH2:8]1)(=[O:25])[CH3:24]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 215146584-(4-Chlorophenyl)-4-(hydroxymethyl)cyclohexan-1-one

생성물 1

HCID 12230249Cyclohexanone, 4-[(acetyloxy)methyl]-4-(4-chlorophenyl)-수율 66%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The 4-hydroxymethyl-4-(4-chlorophenyl)cyclohexanone is dissolved in 60 ml. of pyridine and 30 ml. of acetic anhydride. After about 20 hours of standing at room temperature, the mixture is poured into ice and water. The gum that precipitates is extracted with ether. The organic layer is washed successively with water, 2.5 N hydrochloric acid, water, sodium bicarbonate solution and brine, and evaporated to dryness to give 12.8 g. (66% yield) of 4-acetoxymethyl-4-(4-chlorophenyl)cyclohexanone, as an amorphous gum.

후처리

  1. customThe gum that precipitates
  2. extractionis extracted with ether
  3. washThe organic layer is washed successively with water, 2.5 N hydrochloric acid, water, sodium bicarbonate solution and brine
  4. customevaporated to dryness
  5. customto give 12.8 g

출처 및 근거

ORD 기록
ord-cce86f7717ce486caf8f3b7c5480f6b1
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03979444

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